Press Release

New Array for Studying Interactions Between Transcription Factors

Redwood City, Calif. August 26, 2002—Panomics, Inc. introduces the TF-TF Interaction Array II. This new array represents a significant improvement over co-immunoprecipitation and super-gel shift assays. In contrast to these time-consuming and inefficient assays, TF-TF Interaction Arrays allow assessment of interactions between multiple transcription factors (TFs)—in a single hybridization experiment.

TF-TF Interaction Arrays use a proprietary, patent-pending technology for detecting interactions between TFs. Instead of directly measuring interactions between proteins, this Array employs an exquisitely sensitive indirect approach. This technology is based on the fact that every TF has its own responsive DNA binding element, or cis-element. TF-TF interactions can be assessed by looking at the bound cis-elements—i.e., the interactions can be indirectly visualized when corresponding cis-elements are hybridized to the membrane.

The TF-TF Interaction Array II, which is spotted with 96 TFs, is the second in Panomics’ series of TF-TF Interaction Arrays. Version I is spotted with 54 TFs. By combining both versions, a total of 150 unique TFs can be studied.