Press Release

New Protein/DNA Array for High-throughput Function Analysis for Panomics, Inc.

Redwood City, Calif. June 15, 2001—Panomics, Inc. introduces the new MYRIA™ Protein/DNA Array for high-throughput functional analysis of eukaryotic transcription factors (TFs). This patent-pending array-based technology is a significant improvement over cumbersome gel mobility-shift assays, which only permit the characterization of one TF at a time. With this MYRIA Array, the activities of 54 TFs can be characterized simultaneously.

The MYRIA procedure is simple and straightforward, requiring no special equipment for detection. The first step is to prepare nuclear extracts from the two samples being compared. When the MYRIA probe mix is added to the nuclear extracts, DNA/protein complexes form, representing the TFs of interest. The bound probes are separated from the unbound probes. Finally, the formerly TF-bound DNA sequences are hybridized to MYRIA Array membranes and the signal is detected by chemiluminescence. No radioactivity is necessary.